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VER-155008

SKU: orb1300147

Description

VER-155008 is a selective small molecule inhibitor of the Hsp70 family, demonstrating potent activity against HSP70, HSC70, and GRP78 with IC50 values of 0.5 μM, 2.6 μM, and 2.6 μM, respectively, and over 100-fold selectivity versus HSP90. It is a valuable research tool for studying protein folding, oncology, and neurodegenerative diseases in both cellular and biochemical assays.

Research Area

Cell Biology, Metabolism Research, Pharmacology & Drug Discovery, Signal Transduction

Images & Validation

Key Properties

CAS Number1134156-31-2
MW556.4
Purity99.55%
FormulaC25H23Cl2N7O4
SMILESNc1ncnc2n([C@@H]3O[C@H](COCc4ccc(cc4)C#N)[C@@H](O)[C@H]3O)c(NCc3ccc(Cl)c(Cl)c3)nc12
TargetGPCR,Autophagy,HSP
SolubilityH2O:< 1 mg/mL (insoluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.59 mM);DMSO:79.17 mg/mL (142.29 mM)

Bioactivity

Target IC50
HSP70:0.5 μM|GRP78:2.6 μM|HSC70:2.6 μM
In Vivo
In HCT116 tumor bearing mice, VER-155008 (25 or 40 mg/kg, i.v.) demonstrates rapid metabolism and clearance, along with tumor levels below the predicted pharmacologically active level.
In Vitro
VER-155008 inhibits the proliferation of human breast and colon cancer cell lines BT474, MB-468, HCT116, and HT29 with GI50s in the range 5.3-14.4 μM, and induces Hsp90 client protein degradation in both HCT116 and BT474 cells. In the 8505C and FRO cells, VER-155008 reduces the cell viability and elevates the percentage of dead cells in a time- and dose- dependent manner. VER-155008 causes a dose-dependent inhibition of cytokine-dependent AML cell proliferation. VER-155008 shows an effective inhibition of cell proliferation in A549 and H1975 cells.
Cell Research
All cell lines are grown in DMEM/10% FCS with GlutaMAX-I in a humidified atmosphere of 5% CO2 in air. Cell proliferation is determined using the sulforhodamine B (SRB) assay.(Only for Reference)

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

inhibit, Inhibitor, Heat shock proteins, HSC70, HSP, HSP70, GRP78, Autophagy, VER 155008, VER155008, VER-155008

Similar Products

  • VER-155008 [orb1226944]

    >98% (HPLC)

    1134156-31-2

    556.4006

    C25H23Cl2N7O4

    25 mg, 50 mg, 200 mg, 5 mg, 10 mg, 100 mg, 1 g, 500 mg, 2 mg
Quality Guarantee

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Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

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VER-155008 (orb1300147)

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% Tween 80 +
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Available Sizes

Select a size below

2 mg
$ 80.00
5 mg
$ 110.00
1 ml x 10 mM (in DMSO)
$ 120.00
10 mg
$ 130.00
25 mg
$ 210.00
50 mg
$ 340.00
100 mg
$ 540.00
200 mg
$ 730.00
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