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VR-23

SKU: orb1226034

Description

A potent inhibitor of trypsin-like proteasome (IC50=1 nM), chymotrypsin-like proteasome (IC50=50-100 nM) and caspase-like proteasome (IC50=3 uM); targets the β2 of the 20S proteasome catalytic subunit and structurally distinct from other known proteasome inhibitors and selectively kills cancer cells by apoptosis, with little effect on noncancerous cells.

Images & Validation

Key Properties

CAS Number1624602-30-7
MW477.8782
Purity>98% (HPLC)
FormulaC19H16ClN5O6S
SMILESO=S(N1CCN(C2=CC=NC3=CC(Cl)=CC=C32)CC1)(C4=C(C=C(C=C4)[N+]([O-])=O)[N+]([O-])=O)=O
TargetProteasome
Solubility10 mM in DMSO

Bioactivity

In Vivo
VR23 shows effective antitumor and antiangiogenic activities in mice.
In Vitro
VR23 is a novel proteasome inhibitor targeting β2 of the 20S proteasome subunit. VR23 produces a synergistic effect in killing multiple myeloma cells, including those that were resistant to PS-341. VR23 as a structurally novel proteasome inhibitor with desirable properties as an anticancer agent.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

VR23

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    1624602-30-7

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    C19H16ClN5O6S

    10 mg, 50 mg, 100 mg, 200 mg, 25 mg, 1 ml x 10 mM (in DMSO)
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VR-23 (orb1226034)

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Available Sizes

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500 mg
5 mg
$ 90.00
10 mg
$ 130.00
25 mg
$ 220.00
50 mg
$ 370.00
100 mg
$ 600.00
200 mg
$ 870.00