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VR23

SKU: orb1300141

Description

VR23 is a potent and selective proteasome inhibitor, exhibiting nanomolar IC50 values against trypsin-like (1 nM) and chymotrypsin-like (50-100 nM) activities. Its distinct inhibitory profile makes it a valuable research tool for studying proteasome function in cellular and biochemical assays, including investigations into protein degradation pathways and related disease models.

Research Area

Cell Biology, Protein Biochemistry

Images & Validation

Key Properties

CAS Number1624602-30-7
MW477.88
Purity99.62% (May vary between batches)
FormulaC19H16ClN5O6S
SMILES[O-][N+](=O)c1ccc(c(c1)[N+]([O-])=O)S(=O)(=O)N1CCN(CC1)c1ccnc2cc(Cl)ccc12
TargetCaspase,Proteasome,Apoptosis
SolubilityDMSO:29 mg/mL (60.68 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);H2O:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

Target IC50
Trypsin like proteasomes:1 nM|Caspase-like proteasomes:3 μM|Chymotrypsin-like proteasome:50-100 nM
In Vivo
In ATH490 athymic mice engrafted with MDA-MB-231 metastatic breast cancer cells, VR23 (30 mg/kg, i.p.) shows effective antitumor and antiangiogenic activities. VR23 also reduces adverse effects caused by paclitaxel in mice.
In Vitro
In HeLa cells, VR23 induces ubiquitinated proteins accumulation. In RPMI 8226 and KAS 6 cells, VR23 inhibits cell growth with IC50 of 2.94 and 1.46 μM, respectively. VR23 is also equally effective on both bortezomib (BTZ)-sensitive and -resistant RPMI 8226 and ANBL6 cells cells. When used in combination of bortezomib in the cells above, VR23 shows synergistic effects on cell growth inhibition. In addition, VR23 selectively induces cancer cell apoptosis by causing the accumulation of ubiquitinated cyclin E.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

inhibit, Inhibitor, Chymotrypsin-like proteasomes, Caspase-like proteasomes, Apoptosis, Proteasome, Trypsin-like proteasomes, VR23, VR-23, VR 23

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    1624602-30-7

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    C19H16ClN5O6S

    500 mg, 25 mg, 50 mg, 100 mg, 200 mg, 5 mg, 1 g, 10 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

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VR23 (orb1300141)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 ml x 10 mM (in DMSO)
$ 70.00
10 mg
$ 80.00
25 mg
$ 110.00
50 mg
$ 160.00
100 mg
$ 230.00
200 mg
$ 320.00
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