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VU534

SKU: orb1819058

Description

VU534 is a dual-action small molecule that acts as a NAPE-PLD agonist (EC50 = 0.30 µM) and inhibits both FAAH and soluble epoxide hydrolase (sEH IC50 = 1.2 µM). Its modulation of lipid signaling pathways makes it a valuable research tool for in vitro and in vivo studies in cardiometabolic disease research.

Research Area

Metabolism Research, Neuroscience

Images & Validation

Key Properties

CAS Number923509-20-0
MW447.55
Purity99.22%
FormulaC21H22FN3O3S2
SMILESCC1=CC2=C(SC(NC(=O)C3CCN(CC3)S(=O)(=O)C3=CC=C(F)C=C3)=N2)C(C)=C1
TargetFAAH,Epoxide Hydrolase,Phospholipase
SolubilityDMSO:6.25 mg/mL (13.96 mM)

Bioactivity

Target IC50
sEH:1.2 μM|FAAH:1.2 μM|NAPE-PLD:0.30 μM(EC50)
In Vitro
VU534 (30 μM; 24 h) is less cytotoxic to HepG2 and Raw264.7 cell lines. VU534 (3~30 μM; 1 h) can increase NAPE-PLD activity in Raw264.7 cells. VU534 (1 h) can increase NAPE-PLD activity in HepG2 cells with an EC50 value of 1.5 μM. VU534 (5 μM, 1 h) increased NAPE-PLD activity 1.5-fold but did not reverse NAPE-PLD activity inhibited by LEI–401. VU534 (10 μM; 6 h) significantly enhances efferocytosis of bone marrow-derived macrophages but cannot exert this effect when Napepld is knocked out.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

PLD, Epoxide Hydrolase, EpoxideHydrolase, FAAH, sEH, VU 534, VU534, VU-534

Similar Products

  • VU534 [orb2900490]

    >98% (HPLC)

    923509-20-0

    447.55

    C21H22FN3O3S2

    1 g, 500 mg, 50 mg, 100 mg, 25 mg, 2 mg, 5 mg, 10 mg
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Key Properties

No computed properties available.

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VU534 (orb1819058)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 mg
$ 80.00
5 mg
$ 130.00
10 mg
$ 180.00
25 mg
$ 280.00
50 mg
$ 400.00
100 mg
$ 580.00
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