VUF11207 fumarate

SKU: orb1218617

Description

VUF11207 fumarate is an agonist of CXCR7 and a high-potency ligand of CXCR7 (pKi: 8.1).

Images & Validation

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Key Properties

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CAS Number	1785665-61-3
MW	586.65
Purity	>98% (HPLC)
Formula	C₃₁H₃₉FN₂O₈
SMILES	C/C(CN(CCC1N(C)CCC1)C(C2=CC(OC)=C(OC)C(OC)=C2)=O)=C\C3=C(F)C=CC=C3.OC(/C=C/C(O)=O)=O
Target	CXCR
Solubility	DMSO:247 mg/mL (421.03 mM; Need ultrasonic)

Bioactivity

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In Vivo	Animal model: Male c57Bl/6J wild type/WT mice (8 10 week old; 20 25 g; LPS-induced). Dosage: 100 μg/day. Administration: Subcutaneous injection; single daily for 5 days. Result: Significantly decreased the number of osteoclasts and suppressed Cathepsin K mRNA, ranKl and TnF α mRNA expression levels. Reduced the area of LPS-induced bone resorption. Read more...
In Vitro	Cell Viability Assay Cell line: Osteoclast precursor cells (RANKL- and TNF α-induced). Concentration: 0.17 nM (100 ng/mL) Incubation time: 5 days. Result: Showed inhibitory effect on CXCL12. Read more...

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Gene Symbol

CXCR

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