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VV116

SKU: orb1301221

Description

VV116

Research Area

Infectious Disease & Virology

Images & Validation

Key Properties

CAS Number2647442-33-7
MW502.54
Purity99.42%
FormulaC24H30DN5O7
SMILESC(#N)[C@@]1([C@H](OC(C(C)C)=O)[C@H](OC(C(C)C)=O)[C@@H](COC(C(C)C)=O)O1)C=2N3C(=C(C2)[2H])C(N)=NC=N3
TargetRSV,SARS-CoV
SolubilityDMSO:245 mg/mL (487.52 mM)

Bioactivity

In Vivo
METHODS: Mice were infected with MHV and orally treated with different concentrations (25 mg/kg, 50 mg/kg, and 100 mg/kg) of VV116 (JT001), and disease symptoms, including changes in body weight and mortality, were monitored daily. RESULTS High-dose VV116 treatment effectively suppressed viral titers in vivo and alleviated weight loss caused by viral infection.
In Vitro
VV116 (JT001) (0-1000 μM) inhibits RSV replication in A549 cells with an EC50 of 1.20 μM, a CC50 of 95.92 μM, and a selectivity index (SI) of 80.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

JT 001, JT001, JT-001, GS-621763-d1, SARSCoV, SARS-CoV-2, RSV, VV 116, VV116, VV-116
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Key Properties

No computed properties available.

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Protocol Information

VV116 (orb1301221)

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Available Sizes

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1 mg
$ 140.00
5 mg
$ 270.00
1 ml x 10 mM (in DMSO)
$ 340.00
10 mg
$ 410.00
25 mg
$ 730.00
50 mg
$ 1,020.00
100 mg
$ 1,330.00
DispatchUsually dispatched within 3-5 working days
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