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WAY-100635

SKU: orb1705021

Description

WAY-100635 is a high-affinity 5-HT1A receptor antagonist (IC50 = 0.91 nM) and a dopamine D4 receptor agonist (Ki = 3.3 nM). It is widely used in neuroscience research to study serotonin and dopamine systems, employing in vitro binding assays and in vivo models to investigate behaviors, receptor function, and neural circuitry.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number162760-96-5
MW422.56
Purity98.97% (May vary between batches)
FormulaC25H34N4O2
SMILESO=C(N(C1=NC=CC=C1)CCN2CCN(C=3C=CC=CC3OC)CC2)C4CCCCC4
Target5-HT Receptor,Dopamine Receptor
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.73 mM);DMSO:50 mg/mL (118.33 mM)

Bioactivity

Target IC50
5-HT1A receptor:9.71 (pA2)|5-HT1A receptor:8.87 (pIC50)
In Vivo
Treatment with WAY-100635 (1 mg/kg; subcutaneous injection; male Sprague-Dawley rats) abolishes the reduction of the severity of abstinence signs induced by Rhodiola rosea administration in nicotine-dependent rat . Animal Model: Male Sprague-Dawley rats (220-240 g) Dosage: 1 mg/kg Administration: Subcutaneous injection (Pharmacokinetic study) Result: Reduced total abstinence score, increased immobility time and the burying behavior was increased.
In Vitro
The functional properties and binding affinities of WAY-100635 are evaluated in HEK 293 cells stably expressing dopamine D 2L or D 4.4 receptors . WAY-100635 has binding affinities of 940, 370, and 16 nM on D 2L, D 3, and D 4.2 receptors, respectively. Saturation analyses shows that the K d of [ 3 H] WAY-100635 at D 4.2 receptors is 2.4 nM. WAY-100635 is potent agonist in HEK-D 4.4 cells with EC 50 of 9.7 nM. WAY-100635 possesses high affinity for D 4.4 receptor (3.3 nM) .

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

WAY 100635, WAY100635, WAY-100635

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Key Properties

No computed properties available.

Protocol Information

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100 mg
$ 330.00
250 mg
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1 g
$ 1,180.00
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