Cart summary

You have no items in your shopping cart.

WDR5-IN-6

SKU: orb1819103

Description

WDR5-IN-6 is a small molecule inhibitor targeting the WBM site of WDR5, demonstrating synergistic effects with WIN-site inhibitors like OICR-9429. It exhibits potent anti-proliferative and antitumor activity in neuroblastoma cell lines, supporting its use in vitro research for this cancer type.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number326901-92-2
MW327.19
Purity99.69%
FormulaC13H8Cl2N2O2S
SMILESS(=O)(=O)(N1C=2C(N=C1)=CC=CC2)C3=C(Cl)C=CC(Cl)=C3
TargetJAK
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.11 mM);DMSO:50 mg/mL (152.82 mM)

Bioactivity

In Vitro
WDR5-IN-6 (compound 19) inhibits the proliferation of IMR32 and LAN5 cells with EC50 values of 12.34 and 14.89 μM, respectively, exhibits moderate inhibitory effects on SK-N-AS cells, and shows no effect on HEK293T cells at 20 μM.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

WDR5, WDR5IN6, WDR5-IN-6

Similar Products

  • WDR5-IN-6 [orb2900506]

    >98% (HPLC)

    326901-92-2

    1 g, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 500 mg, 2 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

WDR5-IN-6 (orb1819103)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 80.00
5 mg
$ 130.00
10 mg
$ 190.00
25 mg
$ 340.00
50 mg
$ 520.00
100 mg
$ 810.00
500 mg
$ 1,590.00
DispatchUsually dispatched within 3-5 working days
Bulk Enquiry