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Wighteone

SKU: orb1681466

Description

Wighteone (Erythrinin B) is a natural compound isolated from Genista ephedroides. It exhibits promising antifungal properties and has demonstrated anticancer activity in vitro against NSCLC harboring EGFR L858R/T790M mutations, making it a candidate for targeted therapy research.

Research Area

Infectious Disease & Virology

Images & Validation

Key Properties

CAS Number51225-30-0
MW338.35
Purity98.95% (May vary between batches)
FormulaC20H18O5
SMILESO=C1C(=COC2=CC(O)=C(C(O)=C12)CC=C(C)C)C=3C=CC(O)=CC3
TargetAntifungal
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (9.75 mM);DMSO:80 mg/mL (236.44 mM)

Bioactivity

In Vitro
The limitations of currently available antifungal agents and the rapid emergence of drug-resistant strains necessitate more efficient approaches to screening and developing novel antifungal drugs. METHODS AND RESULTS: The antifungal activity of the natural products of a series of plants was evaluated and Wighteone, 5, 7, 4'-trihydroxy-6-(gamma,gamma-dimethylallyl)isoflavone showed excellent anti-yeast activity (MIC against Saccharomyces cerevisiae was 4 microg/ml). METHODS AND RESULTS: Transcriptome profiling of Wighteone-treated S. cerevisiae indicated that Wighteone is different from commonly used antifungal compounds in its mode of action.

Storage & Handling

Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

6-Isopentenylgenistein, Antifection, HSP90, Fungal, Erythrinin B, Wighteone

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  • Wighteone [orb2900227]

    >98% (HPLC)

    51225-30-0

    338.35

    C20H18O5

    1 g, 500 mg, 100 mg, 5 mg, 10 mg, 25 mg, 50 mg
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Key Properties

No computed properties available.

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Wighteone (orb1681466)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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2 mg
$ 120.00
5 mg
$ 170.00
10 mg
$ 250.00
25 mg
$ 460.00
50 mg
$ 710.00
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