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Wilforlide A

SKU: orb1221739

Description

Wilforlide A, also known as Regelide and Abruslactone A, is an active compound in Tripterygium wilfordii Hook F (TW) which is a traditional Chinese medicine for treatment of autoimmune diseases, is a quality control marker for TW product.

Images & Validation

Key Properties

CAS Number84104-71-2
MW454.7
Purity>98% (HPLC)
FormulaC30H46O3
SMILESO[C@@H]1C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C)[C@H]6OC(=O)[C@](C)(C6)C[C@H]5C4=CC[C@@H]3[C@]2(CC1)C
TargetLipase
SolubilityIn Vitro: DMSO : 1 mg/mL (2.20 mM)

Bioactivity

In Vivo
Wilforlide A (60-300 μg/kg) markedly inhibits mice auricular swelling induced by dimethylbenzene in ICR mice. Wilforlide A exhibits inhibition rates with 50.9% and 12.29% for high dose and low dose Wilforlide A, resepectively. Wilforlide A (30-150 μg/kg) markedly inhibits rat granulation induced by tampon.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Wilforlide A | Regelide | Abruslactone A

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Wilforlide A (orb1221739)

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% DMSO +
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% Tween 80 +
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Available Sizes

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100 mg
200 mg
500 mg
2 mg
$ 110.00
5 mg
$ 170.00
10 mg
$ 220.00
25 mg
$ 380.00