WKYMVM 2TFA(187986-17-0(free base))

SKU: orb1299780

Description

WKYMVM 2TFA is a synthetic hexapeptide and potent agonist of the formyl peptide receptor 1 (FPR1). It is widely used in research to study neutrophil chemotaxis, inflammation, and immune signaling pathways in both in vitro cellular assays and in vivo models of inflammatory disease.

Images & Validation

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Key Properties

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MW	1084.16
Purity	95.43% (May vary between batches)
Formula	C₄₅H₆₃F₆N₉O₁₁S₂
SMILES	OC(=O)C(F)(F)F.OC(=O)C(F)(F)F.CSCC[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCSC)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)C(C)C)C(N)=O
Target	Others
Solubility	DMSO:255 mg/mL (235.21 mM)

Bioactivity

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In Vivo

Using blood samples withdrawn from 28 AL patients and 31 healthy controls, found that, in the absence of exogenous WKYMVM, WKYMVM receptor and bactericidal activity did not differ between patients and controls.Addition of WKYMVM markedly increased the bactericidal activities of these cells in a dose-dependent manner.During induction chemotherapy, there were significant increases in bactericidal activity in the presence and absence of 1nM WKYMVM, with higher bactericidal activities at the time of complete remission than at the time of diagnosis or on day 15.During consolidation chemotherapy, WKYMVM had no effect on bactericidal activities.Patients showed significant increase in the concentrations of TNF alpha, IL-1b, IL-6 and IL-8, but significant decrease in the concentrations of IL-2, IL-4 and IL-12.TNF alpha, IL-1b and IL-6 showed significant negative correlations with bactericidal activities of patient neutrophils at time of diagnosis, and IL-4 showed a significant positive correlation with bactericidal activities,these findings indicate that WKYMVM enhances bactericidal activity in patients with AL.

In Vitro

Neutrophils are activated by WKYMVM through FPRL1 and that FPRL2 is a chemotactic receptor transducing signals in myeloid cells.

Storage & Handling

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Storage	-20°C
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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FPR1, WKYMVM 2TFA(187986 17 0(free base)), WKYMVM 2TFA(187986170(free base)), WKYMVM 2TFA(187986-17-0(free base))

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Compound Identifiers

PubChem CID

155977527 ↗

Key Properties

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No computed properties available.

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