Xentuzumab Antibody

SKU: orb1980648

Description

Xentuzumab (BI836845) is a humanized monoclonal antibody that blocks IGF1 and IGF2 signaling, thereby inhibiting AKT activation and tumor growth. It is utilized in preclinical research for studying solid tumors, including breast and prostate cancers, in both in vitro and in vivo experimental models.

Research Area

Signal Transduction

Images & Validation

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Key Properties

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CAS Number	1417158-65-6
MW	143.7 kDa
Purity	95.21%
Target	IGF-1R,Akt

Bioactivity

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In Vivo

Monotherapy with ENZA did not inhibit tumor growth. However, the addition of Xentuzumab(XENT)rendered the tumors sensitive to ENZA again, leading to a significant reduction in tumor volume.

In Vitro

After 5 or 10 days of incubation, single-agent Xentuzumab(XENT)or ENZA reduced the viability of VCaP, DuCaP, and MDA PCa 2b cells in a dose-dependent manner. Combination therapy further decreased cell viability compared to monotherapy; likewise, treatment with XENT+ENZA resulted in a significant reduction in the expression of cell cycle genes, ubiquitin-conjugating enzyme E2 C (UBE2C), cyclin-dependent kinase 1 (CDK1), and cell division cycle protein 20 (CDC20) compared to single-agent treatment..

Storage & Handling

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Storage	Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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IGF-1R, IGF1R, BI 836845, Akt

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Gene Symbol

IGF-1R,Akt

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