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XL019

SKU: orb1223549

Description

XL019 is a potent and selective JAK2 inhibitor with IC50 of 2.2 nM, exhibiting >50-fold selectivity over JAK1, JAK3 and TYK2. Phase 1.(In Vivo):XL019 (100-300 mg/kg; p.o.; twice daily for 14 days) inhibits HEL.92.1.7 xenograft tumor growth.XL019 (10 mg/kg) treatment shows that the Cmax, t1/2 and Vd were 5.24 μM, 1.94 hours, 5.319 L/kg, respectively.

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Key Properties

CAS Number945755-56-6
MW444.53
Purity>98% (HPLC)
FormulaC25H28N6O2
SMILESO=C([C@H]1NCCC1)NC2=CC=C(C3=NC(NC4=CC=C(N5CCOCC5)C=C4)=NC=C3)C=C2
TargetFLT
SolubilityDMSO: 16 mg/mL (35.99 mM)

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

XL019 | XL-019 | XL 019

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  • XL019 [orb1304569]

    99.19%

    945755-56-6

    444.53

    C25H28N6O2

    5 mg, 10 mg, 50 mg, 100 mg, 25 mg, 1 ml x 10 mM (in DMSO), 2 mg, 200 mg
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XL019 (orb1223549)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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Available Sizes

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200 mg
500 mg
5 mg
$ 120.00
10 mg
$ 190.00
25 mg
$ 320.00
50 mg
$ 500.00
100 mg
$ 730.00