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XYLOBIOSE

SKU: orb1301489

Description

Xylobiose is a natural disaccharide with potential anti-obesity properties. Research indicates it may suppress fat accumulation and ameliorate associated metabolic disorders, making it a candidate for metabolic disease studies in both cellular and animal models.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Signal Transduction

Images & Validation

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XYLOBIOSE

Key Properties

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CAS Number6860-47-5
MW282.24
Purity99.93% (May vary between batches)
FormulaC10H18O9
SMILESO[C@@H]1CO[C@@H](O[C@@H]2COC(O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O
TargetTight Junction Protein,TNF,HSP,IL Receptor
SolubilityDMSO:60 mg/mL (212.59 mM)

Bioactivity

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In Vivo
Mice received a 60% high-fat diet supplemented with 15% d-xylose, 10% XYLOBIOSE, or 15% XYLOBIOSE as part of the total sucrose content of the diet for ten weeks. Body weight, fat and liver weights, fasting blood glucose, and blood lipids levels were significantly reduced with XYLOBIOSE supplementation. Levels of leptin and adipokine were also improved and lipogenic and adipogenic genes in mesenteric fat and liver were down-regulated with XYLOBIOSE supplementation. Furthermore, pro-inflammatory cytokines, fatty acid uptake, lipolysis, and β-oxidation-related gene expression levels in mesenteric fat were down-regulated with XYLOBIOSE supplementation.XYLOBIOSE exhibits anti-diabetic, hypolipogenic, and anti-inflammatory effects via regulation of the miR-122a/33a axis in db/db mice.
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Animal Research
The mice were randomized into five groups: (a) a control group (Ctrl, n = 10) which received a diet of modified American Institute of Nutrition (AIN)-93G (17% of the calories are from fat); (b) a high fat diet (HFD)-induced obesity control group (HF, n = 13) which received a HFD comprised of 60% fat; (c) a xylose 15% group (Xylo 15) which received a HFD with 15% of the total sucrose replaced with d-xylose (n = 13); (d) an XYLOBIOSE 10% group (XYLOBIOSE 10, n = 13) which received a HFD with 10% of the total sucrose replaced by XYLOBIOSE; and (e) an XYLOBIOSE 15% group (XYLOBIOSE 15, n = 12) which received a HFD with 15% of the total sucrose replaced by XYLOBIOSE. Commercially available D-xylose was included as a positive control and was administered at a dose comparable to XYLOBIOSE. The mice were maintained on these diets according to their group for ten weeks prior to sacrifice. Body weight and food intake were measured twice a week.
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Storage & Handling

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StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

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Disaccharide, inhibit, Inhibitor, ILReceptor, IL-1β, IL Receptor, XYLOBIOSE, TNF-α

Similar Products

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  • XYLOBIOSE

    XYLOBIOSE [orb1220689]

    >98% (HPLC)

    6860-47-5

    282.24

    C10H18O9?

    5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 1 g, 500 mg, 200 mg
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Compound Identifiers

PubChem CID
439538 ↗

Key Properties

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No computed properties available.

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XYLOBIOSE (orb1301489)

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Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 ml x 10 mM (in DMSO)
$ 90.00
5 mg
$ 90.00
10 mg
$ 130.00
25 mg
$ 180.00
50 mg
$ 240.00
100 mg
$ 340.00
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