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YJ1206

SKU: orb3033007

Description

YJ1206 is an orally bioavailable PROTAC compound that selectively degrades CDK12 and CDK13, demonstrating potent activity (IC50 = 12.55 nM) in VCaP cells. It induces DNA damage, triggers apoptosis, and drives tumor regression in treatment-resistant prostate cancer PDX models, highlighting its therapeutic potential.

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Key Properties

CAS Number3053716-98-3
MW894.01
Purity>98%
FormulaC49H52FN11O5
SMILESO=C(NCC1=CC=CC=C1)N(C2=CN=C(N3CCN(C4CCN(C5=C(F)C=C(C(N(C6CCC(NC6=O)=O)C7=O)=O)C7=C5)CC4)CC3)C=C2)[C@H](CC8)CC[C@@H]8NC9=NC=C%10C(C=CC=C%10)=N9

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DisclaimerFor research use only

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YJ1206 (orb3033007)

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% DMSO +
%+
% Tween 80 +
%

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25 mg
$ 760.00
DispatchUsually dispatched within 5-10 working days
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