YM-90709

SKU: orb1304505

Description

YM-90709 is a novel small molecule antagonist that selectively blocks the interleukin-5 (IL-5) and IL-5 receptor interaction. It is a valuable research tool for studying eosinophil biology and has demonstrated utility in both in vitro assays and in vivo models of allergic asthma and other eosinophilic diseases.

Research Area

Immunology & Inflammation

Images & Validation

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Key Properties

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CAS Number	163769-88-8
MW	359.42
Purity	99.67%
Formula	C₂₂H₂₁N₃O₂
SMILES	COc1cc2CC(C)(C)n3c(cc4nc5ccccc5nc34)-c2cc1OC
Target	IL Receptor,Interleukin
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.56 mM);DMSO:18 mg/mL (50.08 mM)

Bioactivity

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In Vivo

YM-90709 suppresses antigen-induced airway inflammation in Brown Norway rats . YM-90709 is a novel IL-5R antagonist with those of anit-IL-5 mAb on the antigen-induced infiltration of eosinophils into the airways of BDF1 mice, a strain that is commonly used in the antibody estimation. This is the first report on the examination of the effects of YM-90709 in vivo, as a novel IL-5R antagonist on the antigen-induced infiltration of eosinophils and other leukocytes into the BALF of Brown-Norway (BN) rats.

In Vitro

YM-90709 potently inhibits the binding of 100 pM [125I]-IL-5 to IL-5R on human peripheral eosinophils and eosinophilic HL-60 clone 15 cells with IC50 values of 1.0±0.40 and 0.57±0.21 μM, respectively. YM-90709 inhibits the 4 pM IL-5-induced effect in a concentration-dependent manner with an IC50 value of 0.45±0.024 μM. YM-90709 also inhibits the higher concentrations (12 and 40 pM) of IL-5-induced effects with IC50 values of 0.89±029 and 1.0±0.22 μM, respectively. YM-90709 is a novel interleukin-5 receptor antagonist, YM-90709 inhibits antigen-induced eosinophil recruitment into the airway, the same as anti-IL-5 mAb does. YM-90709 inhibits the binding of IL-5 to IL-5R on human eosinophils, but did not inhibit the binding of GM-CSF to GM-CSFR. In addition, YM-90709 inhibits IL-5-induced, but not GM-CSF-induced, eosinophil survival as well as the tyrosine phosphorylation of Janus kinase 2.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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JAK2, inhibit, ILReceptor, IL-5, IL-5R, Inhibitor, Interleukin Related, Interleukin, IL Receptor, eosinophils, GM-CSF, YM90709, YM-90709, YM 90709

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Compound Identifiers

PubChem CID

1103147 ↗

Key Properties

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No computed properties available.

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Purity:	>98% (HPLC)
CAS Number:	163769-88-8
MW:	359.4
Formula:	C₂₂H₂₁N₃O₂

YM-90709

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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