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YNT-185 dihydrochloride

SKU: orb1693154

Description

This small molecule is a potent and selective OX2 receptor agonist (hOX2 EC50 = 28 nM; >100-fold selective over hOX1). It depolarizes histaminergic neurons in vitro and promotes wakefulness in wild-type mice while suppressing cataplexy in orexin-deficient models, making it a valuable tool for studying sleep/wake regulation and narcolepsy.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number1804978-82-2
MW688.67
FormulaC33H39Cl2N5O5S
SMILESCl.Cl.COc1ccc(cc1S(=O)(=O)Nc1cccc(NCCNC(=O)c2ccccc2N(C)C)c1)-c1cccc(c1)C(=O)N(C)C
TargetOthers,OX Receptor

Storage & Handling

Storage-20°C
DisclaimerFor research use only
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YNT-185 dihydrochloride (orb1693154)

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