Yuanhuacine

SKU: orb3054660

Description

Gnidilatidin is a biochemical.

Images & Validation

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Key Properties

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CAS Number	60195-70-2
MW	648.749
Purity	>98% (HPLC)
Formula	C₃₇H₄₄O₁₀
Solubility	DMSO : 100 mg/mL (154.14 mM; ultraphonic)

Bioactivity

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In Vivo

Animal model: H1993 cells implanted xenograft mouse model. Dosage: 0.5, 1 mg/kg; daily; 21 days. Administration: Oral. Result: Inhibited tumor growth by 33.4% and 38.8%, respectively, reduced tumor weight, activated AMPK, and inhibited proliferation biomarkers Ki-67 and PCNA in tumor tissues.

In Vitro

Cell Viability Assay Cell line: H1993 cell. Concentration: 0, 0.00128, 0.0064, 20, 100 μM Incubation time: 24, 48, 72 h. Result: Inhibited cell proliferation in a concentration- and time-dependent manner. Western blot analysis. Cell line: H1993 cell. Concentration: 0, 10, 100, 500, 1000 nM. Incubation time: 24 h. Result: Significantly increased p-AMPK protein levels, decreased ACC levels, inhibited the autophosphorylation of mTOR at Ser2481 site, inhibited Akt, PKC-α, Rac1 and F-actin, and activated the cell adhesion molecule E-cadherin expression. Cell Migration Assay Cell line: H1993 cell. Concentration: 10, 100 nM. Incubation time: 0, 24 h. Result: Inhibited cell migration in a concentration-dependent manner. Cell Viability Assay Cell line: T24T, UMUC3, HCT116. Concentration: 0, 2, 4, 8, 16 μM. Incubation time: 24 h. Result: Inhibited cell proliferation in a dose-dependent manner. Cell Cycle Analysis Cell line: T24T, HCT116. Concentration: 2 μM. Incubation time: 12 h. Result: Induced significant G2/M phase arrest. Western blot analysis. Cell line: T24T, HCT116. Concentration: 0, 1, 2 μM. Incubation time: 12 h. Result: Up-regulated the expression of p21 protein, but did not show observable induction of p53 protein expression and p53 protein Ser-15 phosphorylation site.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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CAS Number:	60195-70-2
MW:	648.749
Formula:	C₃₇H₄₄O₁₀

Yuanhuacine

Description

Images & Validation

Key Properties

Bioactivity

Storage & Handling

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Yuanhuacine [orb1697066]

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Yuanhuacine (orb3054660)

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