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YUM70

SKU: orb1218039

Description

YUM70 is a potent and selective glucose-regulated protein 78 (GRP78) inhibitor(with an IC50 of 1.5 μM for inhibiting GRP78 ATPase activity of the full-length protein). It induces endoplasmic reticulum (ER) stress-mediated apoptosis in pancreatic cancer.

Images & Validation

Key Properties

CAS Number423145-35-1
MW398.84
Purity>98% (HPLC)
FormulaC21H19ClN2O4
SMILESO=C(CCC)NC(C1=CC=C2C(OCO2)=C1)C(C=C(Cl)C3=C4N=CC=C3)=C4O
TargetGPR
SolubilityDMSO:100 mg/mL (250.73 mM; Need ultrasonic)

Bioactivity

In Vivo
Animal model: 8-week old female NCr nude mice were injected with MIA PaCa-2 cells. Dosage: 30 mg/kg. Administration: i.p. 5 days a week for 7 weeks. Result: Observed a significant tumor growth delay with no significant change in body weight during the course of treatment.
In Vitro
Western blot analysis. Cell line: MIA PaCa-2, PANC-1 cells. Concentration: 0.1, 1, 2.5, 5, 10 μM Incubation time: 2, 4, 8, 24, 48 hours. Result: Increased the protein levels of FAM129A, DDIT3, CHAC-1, DDIT4, UPP1, and GRP78 in a dose- and time-dependent manner.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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  • YUM70 [orb1298541]

    98.01% (May vary between batches)

    423145-35-1

    398.84

    C21H19ClN2O4

    1 mg, 10 mg, 50 mg, 100 mg, 1 ml x 10 mM (in DMSO), 200 mg, 5 mg, 25 mg
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YUM70 (orb1218039)

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Available Sizes

Select a size below

200 mg
500 mg
5 mg
$ 220.00
10 mg
$ 320.00
25 mg
$ 620.00
50 mg
$ 900.00
100 mg
$ 1,270.00