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Z21115

SKU: orb2663581

Description

Z21115 is a potent and orally active PDE4 inhibitor, specifically targeting PDE4D7 (IC50 = 10.5 nM). It reduces pro-inflammatory markers like IL-6 and TNF-α in vitro and shows efficacy in a DSS-induced colitis mouse model, demonstrating anti-inflammatory activity with a high tolerability profile.

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number2958668-54-5
MW390.38
FormulaC20H20F2N2O4
SMILESFC(F)OC1=CC=C(C=2C=C(OC)C(OC)=C(OC)C2)C3=CN(N=C13)C4CC4
TargetPDE

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only
Quality Guarantee

Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

Z21115 (orb2663581)

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