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Zileuton

SKU: orb1310574

Description

Zileuton

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Neuroscience

Images & Validation

Key Properties

CAS Number111406-87-2
MW236.29
Purity99.43%
FormulaC11H12N2O2S
SMILESC(N(C(N)=O)O)(C)C1=CC=2C(S1)=CC=CC2
TargetFerroptosis,COX,Lipoxygenase
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:10 mg/mL (42.32 mM);DMSO:126 mg/mL (533.24 mM)

Bioactivity

In Vivo
Zileuton inhibited PGE2 production in lipopolysaccharide-stimulated human whole blood. In rat carrageenan gum-induced pleurisy, Zileuton decreased PGE2 and 6-ketoprostaglandin F1α pleural levels. In activated mouse peritoneal macrophages and macrophage J774, Zileuton significantly reduced PGE2 and 6-keto prostaglandin F1α levels. In macrophages, Zileuton inhibited PG biosynthesis by interfering with arachidonic acid release.
In Vitro
Zileuton inhibited PGE2 production in lipopolysaccharide-stimulated human whole blood. In rat carrageenan gum-induced pleurisy, Zileuton decreased PGE2 and 6-ketoprostaglandin F1α pleural levels. In activated mouse peritoneal macrophages and macrophage J774, Zileuton significantly reduced PGE2 and 6-keto prostaglandin F1α levels. In macrophages, Zileuton inhibited PG biosynthesis by interfering with arachidonic acid release.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

COX-1, A64077, A-64077, A 64077, Abbott 64077, Abbott64077, Abbott-64077, 5-Lipoxygenase, Ferroptosis, inhibit, Lipoxygenase, LOX, Inhibitor, Zileuton

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Key Properties

No computed properties available.

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Zileuton (orb1310574)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

10 mg
$ 70.00
1 ml x 10 mM (in DMSO)
$ 90.00
25 mg
$ 90.00
50 mg
$ 110.00
100 mg
$ 130.00
200 mg
$ 170.00
500 mg
$ 250.00
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