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ZM 336372

SKU: orb1225710

Description

ZM 336372 is a potent, specific inhibitor of Raf isoforms in vitro (c-Raf IC50=70 nM), paradoxically induces >100-fold activation of c-Raf (Raf-1 activator), but without triggering any activation of MKK1 or p42 MAPK/ERK2; suppresses growth and neuroendocrine hormone levels in carcinoid tumor cells, with marked induction of the cell cycle inhibitors p21 and p18; blocks cellular proliferation and suppresses NE vasoactive peptide production in pheochromocytoma cells.

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Key Properties

CAS Number208260-29-1
MW389.4
Purity>98% (HPLC)
FormulaC23H23N3O3
SMILESO=C(NC1=CC=C(C)C(NC(C2=CC=C(O)C=C2)=O)=C1)C3=CC=CC(N(C)C)=C3
TargetRaf
Solubility10 mM in DMSO

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

ZM336372 | ZM-336372

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  • ZM 336372 [orb1307326]

    97.24%

    208260-29-1

    389.45

    C23H23N3O3

    25 mg, 50 mg, 100 mg, 1 ml x 10 mM (in DMSO), 5 mg, 10 mg, 2 mg
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Protocol Information

ZM 336372 (orb1225710)

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Available Sizes

Select a size below

200 mg
500 mg
2 mg
$ 80.00
5 mg
$ 100.00
10 mg
$ 150.00
25 mg
$ 240.00
50 mg
$ 420.00
100 mg
$ 710.00