ZM39923 hydrochloride

SKU: orb1227140

Description

ZM39923 is a potent, selective JAK3 inhibitor with pIC50 of 7.1, also potently inhibits human tissue transglutaminase (TGM2) with IC50 of 10 nM; ZM39923 is less potent for EGFR, JAK1 and CDK4 with pIC50 of 5.6, 4.4 and < 5.0, no activity fgor JAK2; alteres TGM2 activity in polyglutamine-expressing Drosophila model of neurodegeneration and is found to improve survival; significantly attenuates CCR7-induced Jak3 phosphorylation in metastatic SCCHN cells.

Images & Validation

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Key Properties

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CAS Number	1021868-92-7
MW	367.9117
Purity	>98% (HPLC)
Formula	C₂₃H₂₆ClNO
SMILES	CC(C)N(CCC(=O)C1=CC2=CC=CC=C2C=C1)CC3=CC=CC=C3.Cl
Target	JAK
Solubility	DMSO: ≥ 47 mg/mL

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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ZM-39923 hydrochloride

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Gene Symbol

JAK

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