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Zoledronic Acid

SKU: orb1300511

Description

Zoledronic acid is a bisphosphonate used to treat bone disorders including Paget's disease, osteoporosis, and malignancy-related hypercalcemia. It is widely applied in oncology and bone metabolism research, with studies demonstrating its efficacy in inhibiting osteoclast-mediated bone resorption in both in vitro and in vivo models.

Research Area

Cell Biology, Infectious Disease & Virology

Images & Validation

Key Properties

CAS Number118072-93-8
MW272.09
Purity99.93% (May vary between batches)
FormulaC5H10N2O7P2
SMILESC(P(=O)(O)O)(P(=O)(O)O)(CN1C=CN=C1)O
TargetAutophagy,Antibacterial,Apoptosis,Rho
Solubility0.1M NAOH:12.5 mg/mL (45.94 mM);DMSO:< 1 mg/mL (insoluble or slightly soluble);H2O:1.6 mg/mL (5.88 mM)

Bioactivity

In Vivo
Zoledronic acid (120 mg/kg, subcutaneously) prevented damage formation, prevented cancellous bone loss and loss of bone mineral density, and reduced osteoclast circumference in 5T2 mM mice, also decreasing paraprotein concentration and tumor load, and reducing angiogenesis.
In Vitro
Zoledronic acid (120 mg/kg, subcutaneously) prevented damage formation, prevented cancellous bone loss and loss of bone mineral density, and reduced osteoclast circumference in 5T2 mM mice, also decreasing paraprotein concentration and tumor load, and reducing angiogenesis.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

CGP4244, CGP42446, CGP-42446, CGP42446A, CGP 4244, CGP 42446, activity, anti-resorptive, Autophagy, Apoptosis, bisphosphonate, osteoporosis, osteoclast, Rho, ZOL 446, ZOL446, ZOL-446, Zoledronate, Zoledronic Acid, Zometa

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

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Zoledronic Acid (orb1300511)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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10 mg
$ 80.00
25 mg
$ 90.00
50 mg
$ 120.00
100 mg
$ 170.00
200 mg
$ 230.00
500 mg
$ 360.00
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