2,3-Dihydroxy-4-methoxyacetophenone

SKU: orb1297141

Description

2,3-Dihydroxy-4-methoxyacetophenone is a natural compound investigated for its neuroprotective properties. Research in vitro and in vivo suggests it may enhance cognitive function, supporting its study as a potential therapeutic candidate for neurodegenerative conditions like Alzheimer's disease.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	708-53-2
MW	182.17
Purity	99.38% (May vary between batches)
Formula	C₉H₁₀O₄
SMILES	COc1ccc(C(C)=O)c(O)c1O
Target	Calcium Channel
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (10.98 mM);DMSO:22.5 mg/mL (123.51 mM)

Bioactivity

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In Vivo

Oral administered of 2,3-dihydroxy-4-methoxyacetophenone (1, 10, 20, 40 and 50mg/kg) to amnesic mice induced by scopolamine. In Morris water maze test, 2,3-dihydroxy-4-methoxyacetophenone (50mg/kg) improved the impairment of spatial memory induced by scopolamine. 2,3-Dihydroxy-4-methoxyacetophenone protect HT22 cells on glutamate induced cell-death in a dose-dependent manner (EC50 value: 10.94μM). Furthermore, 2,3-dihydroxy-4-methoxyacetophenone was found to inhibit [Ca(2+)] accumulation in HT22 cells and had antioxidantive activity. 2,3-dihydroxy-4-methoxyacetophenone exert neuroprotective and cognitive-enhancing activities through its antioxidant activity. 2,3-dihydroxy-4-methoxyacetophenone improves cognitive function and may be helpful for the treatment of Alzheimer's disease.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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2,3 Dihydroxy 4 methoxyacetophenone, 2,3Dihydroxy4methoxyacetophenone, 2',3'-Dihydroxy-4'-methoxyacetophenone, 2,3-Dihydroxy-4-methoxyacetophenone, Calcium Channel, CalciumChannel, Inhibitor, inhibit

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Compound Identifiers

PubChem CID

12820 ↗

Key Properties

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No computed properties available.

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