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5-HT3 antagonist 5

SKU: orb2900248

Description

5-HT3 antagonist 5 is a quinoxalin-2-carboxamide compound, a 5-HT3 receptor antagonist. 5-HT3 antagonist 5 exerts antagonism on 5-HT3 agonist and 2-methyl-5-HT, and shows anti-depressant effect in mice.

Research Area

Neuroscience; Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number901599-43-7
MW279.29
Purity>98% (HPLC)
FormulaC16H13N3O2
SMILESCOc1ccc(NC(=O)c2cnc3ccccc3n2)cc1
SolubilityIn Vitro: DMSO : 20.83 mg/mL (74.58 mM; Ultrasonic (<60°C)

Bioactivity

In Vivo
5-HT3 antagonist 5 (compound 4c) (1 mg/kg; i.p.; single dose) decreases the duration of immobility and shows anti-depressant effect in FST mice. Animal model: Swiss albino mice (23 ± 2 g). Dosage: 1 mg/kg. Administration: Intraperitoneal injection; single dose; locomotor scores tested 10 min after administration. Result: Reduced the duration of immobility as compared to the vehicle-treated (control) group. Showed no effect on the locomotion of mice as observed in spontaneous locomotor activity.
In Vitro
5-HT3 antagonist 5 (compound 4c) exhibits 5-HT3 receptor antagonisms in longitudinal muscle myenteric plexus preparation from guinea pig ileum against 5-HT3 agonist, 2-methyl-5-HT, with pA2 value of 5.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Protocol Information

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