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AC1903

SKU: orb1220049

Description

AC1903 is a specific inhibitor of TRPC5 channel, and has been shown to suppress severe proteinuria and prevent podocyte loss.AC1903, that specifically blocks TRPC5 channel activity in glomeruli of proteinuric rats. Chronic administration of AC1903 suppressed severe proteinuria and prevented podocyte loss in a transgenic rat model of FSGS.AC1903 also provided therapeutic benefit in a rat model of hypertensive proteinuric kidney disease. TRPC5 activity drives disease and that TRPC5 inhibitors may be valuable for the treatment of progressive kidney diseases.

Images & Validation

Key Properties

CAS Number831234-13-0
MW303.36
Purity>98% (HPLC)
FormulaC19H17N3O
SMILESC(NC1=NC2=CC=CC=C2N1CC1=CC=CC=C1)C1=CC=CO1
TargetTRP/TRPV Channel
SolubilityIn Vitro: DMSO : 100 mg/mL (329.64 mM)

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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  • AC1903 [orb1298858]

    98.45% (May vary between batches)

    831234-13-0

    303.36

    C19H17N3O

    5 mg, 10 mg, 100 mg, 1 ml x 10 mM (in DMSO), 25 mg, 50 mg
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Protocol Information

AC1903 (orb1220049)

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Available Sizes

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100 mg
200 mg
500 mg
5 mg
$ 100.00
10 mg
$ 150.00
25 mg
$ 290.00
50 mg
$ 470.00