AC1903

SKU: orb1298858

Description

AC1903 is a potent and selective TRPC5 channel inhibitor. Research demonstrates its utility in studying kidney disease mechanisms, as it reduces severe proteinuria and protects against podocyte loss in experimental models. This makes it a valuable tool for renal research.

Research Area

Pharmacology & Drug Discovery

Images & Validation

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Key Properties

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CAS Number	831234-13-0
MW	303.36
Purity	98.45% (May vary between batches)
Formula	C₁₉H₁₇N₃O
SMILES	C(Nc1nc2ccccc2n1Cc1ccccc1)c1ccco1
Target	TRP/TRPV Channel
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.59 mM);DMSO:32.5 mg/mL (107.13 mM)

Bioactivity

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Target IC50	TRPC5 current (HEK-293 cells):14.7 μM (IC50)
In Vivo	AC1903, that specifically blocks TRPC5 channel activity in glomeruli of proteinuric rats. Chronic administration of AC1903 suppressed severe proteinuria and prevented podocyte loss in a transgenic rat model of FSGS.AC1903 also provided therapeutic benefit in a rat model of hypertensive proteinuric kidney disease. TRPC5 activity drives disease and that TRPC5 inhibitors may be valuable for the treatment of progressive kidney diseases. Read more...
Animal Research	Twice-daily intraperitoneal injections of AC1903 (50 mg/kg) for 7 days suppressed severe proteinuria in AT1R Tg rats (Advanced)

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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AC1903, AC-1903, AC 1903, HEK-293, focal segmental, FSGS, glomerulosclerosis, Inhibitor, kidney disease, inhibit, TRPVChannel, TRP Channel, TRPC5, TRPChannel, TRPV Channel, Transient receptor potential channels, proteinuria, ros, podocyte loss

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Compound Identifiers

PubChem CID

667146 ↗

Key Properties

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No computed properties available.

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AC1903 (orb1298858)

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Purity:	>98% (HPLC)
CAS Number:	831234-13-0
MW:	303.36
Formula:	C₁₉H₁₇N₃O

AC1903

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Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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