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Alobresib

SKU: orb1220140

Description

Alobresib is an inhibitor of BET bromodomain,is an antineoplastic drug candidate.in vitro experiments demonstrated high sensitivity of USC cell lines to the exposure to GS-5829, GS-626510, and JQ1 with BET inhibitors causing a dose-dependent decrease in the phosphorylated levels of c-Myc and a dose-dependent increase in caspase activation (apoptosis). In comparative in vivo experiments, GS-5829 and/or GS-626510 were found more effective than JQ1 at the concentrations/doses used in decreasing tumor growth in both USC-ARK1 and USC-ARK2 mouse xenograft models.

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Key Properties

CAS Number1637771-14-2
MW437.5
Purity>98% (HPLC)
FormulaC26H23N5O2
SMILESCc1noc(C)c1-c1cc(c2nc([nH]c2c1)C1CC1)C(O)(c1ccccn1)c1ccccn1
TargetEpigenetic Reader Domain
SolubilityIn Vitro: DMSO : 83.33 mg/mL (190.47 mM)

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Vorolanib,GS-5829

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  • Alobresib [orb1298885]

    98.87% (May vary between batches)

    1637771-14-2

    437.49

    C26H23N5O2

    25 mg, 50 mg, 2 mg, 1 ml x 10 mM (in DMSO), 1 mg, 5 mg, 10 mg, 100 mg
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Alobresib (orb1220140)

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(Recommended: An additional animal making an allowance for loss during the experiment)

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Available Sizes

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200 mg
500 mg
5 mg
$ 220.00
10 mg
$ 400.00
25 mg
$ 750.00
50 mg
$ 1,040.00
100 mg
$ 1,420.00