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Alobresib

SKU: orb1298885

Description

Alobresib (Vorolanib) is a BET bromodomain inhibitor developed as an investigational anticancer agent. It has demonstrated antitumor activity in preclinical studies, including in vitro assays and in vivo models, supporting its research in oncology and targeted therapy.

Research Area

Epigenetics & Chromatin

Images & Validation

Key Properties

CAS Number1637771-14-2
MW437.49
Purity98.87% (May vary between batches)
FormulaC26H23N5O2
SMILESCc1noc(C)c1-c1cc(c2[nH]c(nc2c1)C1CC1)C(O)(c1ccccn1)c1ccccn1
TargetEpigenetic Reader Domain
SolubilityDMSO:27.5 mg/mL (62.86 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.57 mM)

Bioactivity

In Vivo
In comparative in vivo experiments, GS-5829 and/or GS-626510 were found more effective than JQ1 at the concentrations/doses used in decreasing tumor growth in both USC-ARK1 and USC-ARK2 mouse xenograft models
In Vitro
in vitro experiments demonstrated high sensitivity of USC cell lines to the exposure to GS-5829, GS-626510, and JQ1 with BET inhibitors causing a dose-dependent decrease in the phosphorylated levels of c-Myc and a dose-dependent increase in caspase activation (apoptosis).

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Epigenetic Reader Domain, EpigeneticReaderDomain, GS5829, GS-5829, GS 5829, Inhibitor, inhibit, BET, Alobresib, Vorolanib

Similar Products

  • Alobresib [orb1220140]

    >98% (HPLC)

    1637771-14-2

    437.5

    C26H23N5O2

    1 g, 500 mg, 200 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg
Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

Alobresib (orb1298885)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 110.00
2 mg
$ 140.00
5 mg
$ 190.00
1 ml x 10 mM (in DMSO)
$ 210.00
10 mg
$ 330.00
25 mg
$ 610.00
50 mg
$ 840.00
100 mg
$ 1,130.00
DispatchUsually dispatched within 3-5 working days
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