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IGF-1R Biosimilar Antibody
SKU: orb1826913
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Description
Images & Validation
−Item 1 of 3
| Tested Applications | FC |
|---|---|
| Dilution range | Flow Cyt 1:100 |
| Reactivity | Human |
| Application Notes |
Key Properties
−| Antibody Type | Biosimilar Antibody |
|---|---|
| Host | Human |
| Clonality | Monoclonal |
| Isotype | IgG1(E239D, M241L) |
| Target | IGF-1R |
| Purification | Purified from cell culture supernatant by affinity chromatography |
| Conjugation | Unconjugated |
Storage & Handling
−| Storage | Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles. |
|---|---|
| Disclaimer | For research use only |
Alternative Names
−CD221, IGFIR, IGFR, JTK13
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IGF-1R protein is highly expressed on the surface of Expi293 cell membrane. Flow cytometry analysis with 1 μg/mL Anti-IGF-1R (teprotumumab biosimilar) mAb (orb1826913) on Expi293 cells transfected with human IGF-1R (Blue histogram) or Expi293 transfected with irrelevant protein (Red histogram), and Isotype antibody on Expi293 transfected with irrelevant protein (Orange histogram).
Flow cytometry analysis of antigen binding of anti-human IGF-1R mAb (orb1826913). (A) orb1826913 does not bind to Jurkat cells that do not express IGF-1R. (B) A clear peak shift of orb1826913 was seen compared to the control when incubated with IGF-1R-expressing Hela cells, indicating strong binding of orb1826913 to IGF-1R. Antibodies were incubated at 5 μg/mL.
Flow cytometry analysis of antigen binding of anti-human IGF-1R mAb (orb1826913). (A) orb1826913 does not bind to Jurkat cells that do not express IGF-1R. (B) A clear peak shift of orb1826913 was seen compared to the control when incubated with IGF-1R-expressing MCF-7 cells, indicating strong binding of orb1826913 to IGF-1R. Antibodies were incubated at 5 μg/mL.
Quick Database Links
Gene Symbol
IGF-1R
UniProt
UniProt Details
− No UniProt data available
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IGF-1R Biosimilar Antibody (orb1826913)
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