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Apostatin-1

SKU: orb1218272

Description

Apostatin-1 is a novel TRADD inhibitor. Apostatin-1 can bind to a pocket on the N-terminal TRAF2 binding domain of TRADD.

Images & Validation

Key Properties

CAS Number2559703-06-7
MW345.5
Purity>98% (HPLC)
FormulaC19H27N3OS
SMILESO=C(NC1CCCCCC1)C(C2=CC=CC=C2)SC3=NCCN3C
TargetTRADD
SolubilityDMSO:65mg/ml(188.13mM; need ultrasonic); Ethanol:9mg/ml(26.06mM; need ultrasonic)

Bioactivity

In Vivo
Animal model: Wild-type mice (n = 10, male, 8 weeks of age, systemic inflammation mouse model). Dosage: 20 mg/kg. Administration: IP, once. Result: Reduced expression of the TNF-induced inflammatory target gene products, NOS and COXII27, and of inflammatory cytokines in cells stimulated with pathogen-associated molecular patterns, including interferon γ (IFNγ), lipopolysaccharide (LPS), Pam3CSK4 (a synthetic bacterial lipopeptide), and muramyl dipeptide (MDP). Showed increased survival following intravenous delivery of TNF, a mouse model of systemic inflammation.
In Vitro
Western blot analysis. Cell line: SH-SY5Y, HeLa, HT-29, and Jurkat cells. Concentration: 10 μM. Incubation time: 6 h. Result: Effectively induced autophagy by LC3 II induction and p62 reduction.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Apt-1

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    2559703-06-7

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    C19H27N3OS

    2 mg, 5 mg, 10 mg, 25 mg, 50 mg, 100 mg, 500 mg, 1 mg, 1 ml x 10 mM (in DMSO)
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Apostatin-1 (orb1218272)

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Available Sizes

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2 mg
$ 90.00
5 mg
$ 130.00
10 mg
$ 190.00
25 mg
$ 350.00
50 mg
$ 540.00
100 mg
$ 780.00
500 mg
$ 1,660.00