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Apostatin-1

SKU: orb1685322

Description

Apostatin-1 (Apt-1) is a novel small molecule inhibitor that selectively targets the TRAF2-binding domain of TRADD. This mechanism enables its use in vitro and in vivo to investigate TNF signaling pathways, apoptosis, and necroptosis in relevant disease models.

Research Area

Cell Biology, Signal Transduction

Images & Validation

Key Properties

CAS Number2559703-06-7
MW345.5
Purity99.08%
FormulaC19H27N3OS
SMILESCN1CCN=C1SC(C(=O)NC1CCCCCC1)c1ccccc1
TargetOthers,Necroptosis,RIP kinase,Apoptosis,Autophagy
SolubilityEthanol:9 mg/mL (26.05 mM);DMSO:50 mg/mL (144.72 mM)

Bioactivity

In Vitro
Apostatin-1 inhibited bortezomib induced apoptosis and ripk1 dependent apoptosis (RDA) with the IC50 of ~1μM.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Necroptosis, inflammatory responses, inhibit, Jurkat cells, Inhibitor, HeLa, HT-29, beclin 1, Beclin1, Apoptosis, Apostatin 1, Apostatin1, Apostatin-1, Apt-1, Apt1, Apt 1, Autophagy, Atg6, TRADD, RIP kinase, RIPK1, RIPK, SH-SY5Y, Receptor-interacting protein kinases

Similar Products

  • Apostatin-1 [orb1218272]

    >98% (HPLC)

    2559703-06-7

    345.5

    C19H27N3OS

    50 mg, 100 mg, 1 g, 2 mg, 25 mg, 10 mg, 500 mg, 5 mg
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Key Properties

No computed properties available.

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Apostatin-1 (orb1685322)

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Available Sizes

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1 mg
$ 80.00
2 mg
$ 90.00
1 ml x 10 mM (in DMSO)
$ 120.00
5 mg
$ 120.00
10 mg
$ 170.00
25 mg
$ 290.00
50 mg
$ 440.00
100 mg
$ 630.00
500 mg
$ 1,320.00
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