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APY29

SKU: orb1223386

Description

APY29 is a IRE1α inhibitor. The accumulation of unfolded proteins under endoplasmic reticulum (ER) stress leads to the activation of the multidomain protein sensor IRE1α as part of the unfolded protein response (UPR). ATP-competitive inhibitors of IRE1α promote dimerization and activation of RNase activity despite blocking kinase autophosphorylation.

Images & Validation

Key Properties

CAS Number1216665-49-4
MW332.36
Purity>98% (HPLC)
FormulaC17H16N8
SMILESC1CC1c1cc(n[nH]1)Nc1nc(ncc1)Nc1cc2c(cc1)nc[nH]2
TargetP2 Receptor
SolubilityDMSO : 10 mg/mL. 30.09 mM;

Bioactivity

In Vitro
APY29 divergently modulates the RNase activity and oligomerization state of IRE1α. APY29 is exerting their opposing effects on RNase activity through the same binding site. APY29 divergently affects IRE1α oligomerization. APY29 demonstrates opposing dose-dependent effects on ER stress-induced activation of the RNase of endogenous IRE1α.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

APY29 | APY-29 | APY 29

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  • APY29 [orb1303952]

    98.46%

    1216665-49-4

    332.36

    C17H16N8

    2 mg, 50 mg, 10 mg, 100 mg, 1 ml x 10 mM (in DMSO), 5 mg, 25 mg, 500 mg
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APY29 (orb1223386)

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Available Sizes

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2 mg
$ 80.00
5 mg
$ 110.00
10 mg
$ 160.00
25 mg
$ 270.00
50 mg
$ 440.00
100 mg
$ 760.00
500 mg
$ 1,550.00