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APY29

SKU: orb1303952

Description

APY29

Research Area

Cell Biology

Images & Validation

Key Properties

CAS Number1216665-49-4
MW332.36
Purity98.46%
FormulaC17H16N8
SMILESC1CC1c1cc(Nc2ccnc(Nc3ccc4nc[nH]c4c3)n2)n[nH]1
TargetIRE1
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:5 mg/mL (15.04 mM);DMSO:12.5 mg/mL (37.61 mM);H2O:< 1 mg/mL (insoluble)

Bioactivity

Target IC50
IRE1α:280 nM
In Vitro
APY29 selectively influences IRE1α by divergently modulating its RNase activity and oligomerization state through the same binding site, showing opposing effects on RNase activity. Additionally, APY29 has a dose-dependent, contrasting impact on ER stress-induced activation of the endogenous IRE1α RNase .

Storage & Handling

Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

APY 29, APY29, APY-29, Inhibitor, Inositol requiring enzyme 1, IRE1, IRE1α, inhibit

Similar Products

  • APY29 [orb1223386]

    >98% (HPLC)

    1216665-49-4

    332.36

    C17H16N8

    1 g, 100 mg, 500 mg, 2 mg, 5 mg, 10 mg, 25 mg, 50 mg
Quality Guarantee

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Key Properties

No computed properties available.

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Protocol Information

APY29 (orb1303952)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

2 mg
$ 80.00
5 mg
$ 100.00
1 ml x 10 mM (in DMSO)
$ 110.00
10 mg
$ 140.00
25 mg
$ 230.00
50 mg
$ 360.00
100 mg
$ 620.00
500 mg
$ 1,230.00
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