Arbidol hydrochloride

SKU: orb1226553

Description

Arbidol (Umifenovir) hydrochloride is an broad-spectrum antiviral chemical agent which can inhibit cell entry of enveloped viruses by blocking viral fusion with host cell membrane. (In Vitro):Umifenovir hydrochloride exhibits a wide range and potent antiviral activity against a number of viruses including influenza A, B and C viruses, respiratory syncytial virus, adenovirus, parainfluenza type 5 and rhinovirus type 14, avian coronavirus, infectious bronchitis virus and Marek disease virus, hepatitis B virus and hepatitis C virus.(In Vivo):Umifenovir (45-180 mg/kg; p.o.; daily for 5 days) suppresses the transcription of influenza viruses (IFV) -associated inflammatory cytokines.

Images & Validation

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Key Properties

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CAS Number	131707-23-8
MW	513.88
Purity	>98% (HPLC)
Formula	C₂₂H₂₅BrN₂O₃S·HCl
SMILES	Cl.CCOC(=O)C1=C(CSC2=CC=CC=C2)N(C)C2=CC(Br)=C(O)C(CN(C)C)=C12
Target	Influenza Virus
Solubility	Ethanol: 22 mg/mL (42.81 mM); DMSO: 103 mg/mL (200.43 mM)

Bioactivity

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In Vivo	Umifenovir (45-180 mg/kg; p.o. ; daily for 5 days) suppresses the transcription of influenza viruses (IFV)-associated inflammatory cytokines. Animal model: BALB/c mice were infected with A/FM/1/47 (H1N1). Dosage: 45, 90, and 180 mg/kg. Administration: p.o. ; daily for 5 days. Result: Decreased the transcription of cytokines in murine lung following the IFV A (H1N1) Infection. Read more...
In Vitro	Umifenovir hydrochloride exhibits a wide range and potent antiviral activity against a number of viruses including influenza A, B and C viruses, respiratory syncytial virus, adenovirus, parainfluenza type 5 and rhinovirus type 14, avian coronavirus, infectious bronchitis virus and Marek disease virus, hepatitis B virus and hepatitis C virus. Read more...

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Umifenovir

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Influenza Virus

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