Umifenovir hydrochloride

SKU: orb1310932

Description

Umifenovir hydrochloride (Arbidol HCl) is a broad-spectrum antiviral small molecule that inhibits the entry of enveloped viruses by preventing viral-host cell membrane fusion. It has demonstrated antiviral activity in vitro and in vivo against influenza, coronaviruses, and other viruses, making it a useful tool for virology and antiviral mechanism research.

Research Area

Infectious Disease & Virology

Images & Validation

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Key Properties

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CAS Number	131707-23-8
MW	513.88
Purity	99.90% (May vary between batches)
Formula	C₂₂H₂₅BrN₂O₃S·HCl
SMILES	Cl.CCOC(=O)c1c(CSc2ccccc2)n(C)c2cc(Br)c(O)c(CN(C)C)c12
Target	SARS-CoV,Influenza Virus
Solubility	DMSO:250 mg/mL (486.49 mM);H2O:< 1 mg/mL (insoluble or slightly soluble);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.89 mM);Ethanol:21 mg/mL (40.87 mM)

Bioactivity

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Target IC50

RNA viruses(FLU-A, RSV, HRV 14 and CVB3, enveloped and non-enveloped):2.7-13.8 microg/ml

In Vitro

Arbidol inhibits the cell entry of HCV pseudoparticles of genotypes 1a, 1b, and 2a in a dose-dependent fashion. Arbidol also displays a dose-dependent inhibition of HCV membrane fusion, as assayed by using HCV pseudoparticles (HCVpp) and fluorescent liposomes. Arbidol is found to present potent inhibitory activity against enveloped and non-enveloped RNA viruses, including FLU-A, RSV, HRV 14 and CVB3 when added before, during, or after viral infection, with IC50 ranging from 2.7 to 13.8 mg/mL. Arbidol shows selective antiviral activity against AdV-7, a DNA virus, only when added after infection (therapeutic index (TI) = 5.5). Arbidol induces changes to viral mRNA synthesis of the PB2, PA, NP, NA, and NS genes in MDCK cultures infected with influenza A/PR/8/34. Arbidol interacts and modifies the physicochemical properties of the phospholipids in the membrane, having a significant effect on negatively charged phospholipids but a minor one on zwitterionic phospholipids. Arbidol is located at the interface of the membrane, participates in hydrogen bonding either with water or the phospholipid or both, and decreases the hydrogen bonding network of the phospholipids giving place to a phospholipid phase similar to the dehydrated solid one. Arbidol is found to have potent inhibitory activity against HTNV when added in vitro before or after viral infection, with IC50 of 0.9 mg/mL and 1.2 mg/mL, respectively.

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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Arbidol HCl, Arbidol hydrochloride, Arbidol Hydrochloride, Inhibitor, fusion, enveloped, inhibit, InfluenzaVirus, Influenza Virus, inflammatory, Influenza A virus, oral, SARS coronavirus, SARSCoV, SARS-CoV, virus, Umifenovir, Umifenovir hydrochloride, Umifenovir Hydrochloride

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Compound Identifiers

PubChem CID

9958103 ↗

Key Properties

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No computed properties available.

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