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Arbidol

SKU: orb2900414

Description

Umifenovir is a potent, orally active broad-spectrum antiviral agent with activity against a number of enveloped and non-enveloped viruses. Umifenovir is used as an anti-influenza virus agent. Umifenovir could effectively inhibit the fusion of virus with host cells. Umifenovir is an efficient inhibitor of SARS-CoV-2 in vitro. Umifenovir shows anti-inflammatory activity.

Images & Validation

Key Properties

CAS Number131707-25-0
MW477.42
Purity>98% (HPLC)
FormulaC22H25BrN2O3S
SMILESO=C(OCC)C=1C=2C(=CC(Br)=C(O)C2CN(C)C)N(C1CSC=3C=CC=CC3)C
TargetAntiviral
SolubilityIn Vitro: DMSO : 50 mg/mL (104.73 mM; Ultrasonic )

Bioactivity

In Vivo
Umifenovir (25 and 45 mg/ml; p.o.) shows a survival benefit to mice suffering from influenza infection. Animal model: BALB/c mice (6–8 weeks old), mice were intranasally (i. n.) inoculated with 2 times the 50% mouse lethal dose (MLD50) of A/ Guangdong/GIRD07/09 (H1N1) (104.5TCID50/mL) in a volume of 20mL. Dosage: 1.25 mg/mL (25 mg/kg/day) and 2.25 mg/mL (45 mg/kg/day) in a total volume of 500mL at one day pre-infection and 3 days post-infection (dpi). Administration: Oral administration. Result: Increased the survival rate, inhibited the decrease of body weight at 45 mg/mL and inhibited the increase of mice lung index at 25 mg/mL and 45 mg/mL comparing to virus group.
In Vitro
Umifenovir exhibits a wide range and potent antiviral activity against a number of viruses including influenza viruses A, B and C, respiratory syncytial virus, SARS-CoV, adenovirus, parainfluenza type 5, poliovirus 1, rhinovirus 14, coxsackievirus B5, hantaan virus, Chikungunya virus, HBV and HCV.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Arbidol (orb2900414)

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% DMSO +
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% Tween 80 +
%

Available Sizes

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5 mg
$ 70.00
10 mg
$ 90.00
25 mg
$ 150.00
50 mg
$ 230.00
100 mg
$ 330.00
500 mg
$ 750.00