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Avitinib

SKU: orb1304614

Description

Avitinib (AC0010) is an orally bioavailable, irreversible inhibitor that selectively targets mutant epidermal growth factor receptor (EGFR), including the T790M resistance mutation. It is used in oncology research to study tumor growth inhibition in EGFR-mutated models, with applications in both in vitro cellular assays and in vivo xenograft experiments.

Research Area

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Images & Validation

Key Properties

CAS Number1557267-42-1
MW487.53
Purity>99.99% (May vary between batches)
FormulaC26H26FN7O2
SMILESCN1CCN(CC1)c1ccc(Nc2nc(Oc3cccc(NC(=O)C=C)c3)c3cc[nH]c3n2)cc1F
TargetBTK,EGFR,JAK,Apoptosis
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.77 mM);DMSO:88 mg/mL (180.5 mM)

Bioactivity

Target IC50
BTK:0.4 nM|EGFR (WT):7.68 nM|JAK3:0.09 nM|EGFR (L858R/T790M):0.18 nM

Storage & Handling

Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

AC 0010, AC0010, AC-0010, Abivertinib, Avitinib, Btk, BTK, Bruton tyrosine kinase, Epidermal growth factor receptor, ErbB-1, EGFR, Inhibitor, HER1, inhibit, JAK3

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

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Avitinib (orb1304614)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

2 mg
$ 90.00
5 mg
$ 110.00
1 ml x 10 mM (in DMSO)
$ 120.00
10 mg
$ 160.00
25 mg
$ 270.00
50 mg
$ 420.00
100 mg
$ 590.00
DispatchUsually dispatched within 3-5 working days
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