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AX-024

SKU: orb1688965

Description

AX-024 is a potent and selective orally bioavailable small molecule inhibitor of the TCR-Nck interaction, targeting SH3 domains to suppress T cell activation. With an IC50 of ~1 nM, it effectively reduces pro-inflammatory cytokine production (e.g., IL-6, TNF-α, IFN-γ) and demonstrates low acute toxicity, making it a valuable tool for researching T-cell-mediated diseases in both cellular and animal models.

Research Area

Cell Biology, Immunology & Inflammation

Images & Validation

Key Properties

CAS Number1370544-73-2
MW339.4
FormulaC21H22FNO2
SMILESCOc1ccc2OCC(CN3CCCC3)=C(c3ccc(F)cc3)c2c1
TargetInterleukin,Others,TNF,IFNAR

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

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Quality Guarantee

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Key Properties

No computed properties available.

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AX-024 (orb1688965)

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