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Bemnifosbuvir

SKU: orb1298170

Description

Bemnifosbuvir (AT-511) is a phosphoramidate prodrug of a 2'-C-methylguanosine monophosphate analog, demonstrating potent anti-HCV activity in vitro. It is a research compound used in virology and antiviral drug discovery, with studies investigating its efficacy in both cell-based assays and animal models of hepatitis C infection.

Research Area

Infectious Disease & Virology, Protein Biochemistry

Images & Validation

Key Properties

CAS Number1998705-64-8
MW581.53
Purity99.69% (May vary between batches)
FormulaC24H33FN7O7P
SMILESC[C@]1(F)[C@H](N2C=3C(N=C2)=C(NC)N=C(N)N3)O[C@H](COP(OC4=CC=CC=C4)(N[C@H](C(OC(C)C)=O)C)=O)[C@H]1O
TargetSARS-CoV,HCV Protease
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (5.67 mM);DMSO:95 mg/mL (163.36 mM)

Bioactivity

Target IC50
SARS-CoV-2:0.47 μM (EC90)|HCV:5-28 nM (EC50)
In Vivo
Treatment with moxifloxacin every 8hr was accompanied by longer survival than in any other group.Tissue cultures 30hr after bacterial challenge showed considerably less bacterial growth in the spleens and lungs of moxifloxacin-treated animals than in the other groups, but not in their livers.
In Vitro
Bemnifosbuvir is a novel phosphoramidate prodrug of 2'-fluoro-2'-C-methylguanosine-5'-monophosphate that has potent in vitro activity against HCV.In the absence of cells, Bemnifosbuvir was stable when incubated in culture medium at 37°C for up to 24 h. AT-9010 was the predominant intracellular metabolite measured in all hepatocyte species and Huh-7 cell incubations with 10 μM Bemnifosbuvir and, except in mouse hepatocytes,far exceeded intracellular Bemnifosbuvir concentrations,demonstrating that the active TP was efficiently formed from its phosphoramidate protide in liver cells. In hepatocyte incubations, the relative levels of AT-9010 formed, and its accumulation over 24 h expressed as area under the curve or AUC0-24h; from most to least abundant, were rat>human >mouse >dog/monkey.

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

phosphoramidate, SARS-CoV, SARSCoV, SARS coronavirus, Bemnifosbuvir, antiviral, AT 511, AT511, AT-511, Inhibitor, Hepatitis C virus, HCVProtease, HCV Protease, HCV, guanosine, inhibit, nucleotide, pangenotypic

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Key Properties

No computed properties available.

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Bemnifosbuvir (orb1298170)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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1 mg
$ 100.00
5 mg
$ 190.00
1 ml x 10 mM (in DMSO)
$ 240.00
10 mg
$ 290.00
25 mg
$ 460.00
50 mg
$ 640.00
100 mg
$ 840.00
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