beta-Eudesmol

SKU: orb1222225

Description

β-Eudesmol is a noncompetitive antagonist of nicotinic acetylcholine receptors (nAChRs). It is a sesquiterpene that has been found in a variety of plants, including Cannabis, and has diverse biological activities.

Images & Validation

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Key Properties

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CAS Number	473-15-4
MW	222.37
Purity	>98% (HPLC)
Formula	C₁₅H₂₆O
SMILES	CC(C)(O)[C@@H]1CC[C@@]2(C)CCCC(=C)[C@@H]2C1
Target	nAChR\| TRPA1\| TRPV3\| TRPM8
Solubility	In Vitro: DMSO : 100 mg/mL (449.70 mM)

Bioactivity

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In Vivo

Animal model: Male KM mice model. Dosage: 1.25 mg/kg, 2.5 mg/kg, 5 mg/kg. Administration: Intraperitoneal injection (i.p.); Once daily for 7 days. Result: Inhibited the growth of H22 tumor cells with inhibition rates of 39.9% (2.5 mg/kg) and 49.3%(5 mg/kg), respectively. Inhibited the growth of S108 tumor cells with inhibition rates of 22.4% (2.5 mg/kg) and 42.2%(5 mg/kg), respectively. Significantly decreased vascular index with inhibition rates of 34.4% (2.5 mg/kg) and 44.3% (5 mg/kg). Animal model: Male C57BL/6 mice model. Dosage: 50 mg/kg, 100 mg/kg. Administration: Intraperitoneal injection (i.p.); Single dose. 2 h before the cecal ligation and puncture (CLP) operation. Result: Increased the expression of TNF-α, IL-1β and IL-6 in a dose-dependent manner. Increased the levels of superoxide dismutase (SOD) and glutathione (GSH), and decreased the levels of malondialdehyde (MDA) and myeloperoxidase (MPO). Inhibit the phosphorylation of p65.

In Vitro

Western blot analysis. Cell line: HL-60. Concentration: 40 μM, 80 μM. Incubation time: 4 h. Result: Increased the expression of caspase-3 protein at 80 μM. Cell Viability Assay Cell line: HL-60. Concentration: 10 μM, 20 μM, 40 μM, 60 μM, 80 μM, 120 μM. Incubation time: 4 h. Result: Didn’t affect cell activity at a dose of 40 μM, but decreased cell activity at a dose of 80 μM, and cell viability decreased by 51.6%. Apoptosis Analysis Cell line: HL-60. Concentration: 40 μM, 80 μM. Incubation time: 4 h. Result: Had no effect on apoptosis at the dose of 40 μM, but induced apoptosis at the dose of 80 μM, and the apoptosis rate was 31.7%.

Storage & Handling

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Storage	Storage temperature: -20°C. Stability: ≥ 2 years
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

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Gene Symbol

nAChR| TRPA1| TRPV3| TRPM8

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beta-Eudesmol (orb1222225)

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Purity:	98.00% (May vary between batches)
CAS Number:	51317-08-9
MW:	224.39
Formula:	C₁₅H₂₈O

CAS Number:	83217-89-4
MW:	238.37
Formula:	C₁₅H₂₆O₂

Purity:	99.85% (May vary between batches)
CAS Number:	473-15-4
MW:	222.37
Formula:	C₁₅H₂₆O

beta-Eudesmol

Description

Images & Validation

Key Properties

Bioactivity

Storage & Handling

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beta-Eudesmol (orb1222225)

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