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beta-Eudesmol

SKU: orb1303641

Description

Beta-Eudesmol (Beta-Selinenol) is a sesquiterpene natural product that acts as a noncompetitive antagonist of nicotinic acetylcholine receptors (nAChRs). This compound, sourced from plants like Cannabis, is utilized in neuroscience research to study receptor function and modulation in both in vitro and in vivo models.

Research Area

Cell Biology, Immunology & Inflammation, Metabolism Research, Neuroscience, Pharmacology & Drug Discovery, Protein Biochemistry, Signal Transduction

Images & Validation

Key Properties

CAS Number473-15-4
MW222.37
Purity99.85% (May vary between batches)
FormulaC15H26O
SMILES[H][C@@]12C[C@@H](CC[C@@]1(C)CCCC2=C)C(C)(C)O
TargetCaspase,AChR,Reactive Oxygen Species,TNF,ROS,TRP/TRPV Channel
SolubilityDMSO:25 mg/mL (112.43 mM)

Bioactivity

In Vivo
β-Eudesmol also inhibits proliferation of HeLa, SGC-7901, and BEL-7402 cells when used at concentrations ranging from 10 to 100 μM and reduces tumour growth in H22 and S-180 mouse tumor models when administered at doses ranging from 2.5 to 5 mg/kg. β-Eudesmol is an agonist of the transient receptor potential (TRP) receptor subtypes TRPA1, TRPV3, and TRPM8 and increases food intake and plasma levels of ghrelin in rats .
In Vitro
β-Eudesmol is a noncompetitive antagonist of nicotinic acetylcholine receptors (nAChRs) that decreases the open time and opening frequency of nAChR channels when used at concentrations of 40 and 80 μM and increases the decay phase of the depolarization when used at a concentration of 100 μM in isolated mouse diaphragm muscle . β-Eudesmol (50-100 μM) inhibits VEGF- and bFGF-induced proliferation in human umbilical vein endothelial cells (HUVECs) .

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Beta-Selinenol, b-Eudesmol, b-Selinenol, beta Eudesmol, betaEudesmol, Beta-Eudesmol, beta-Eudesmol, nAChR, inhibit, Inhibitor, β-Eudesmol, β-Selinenol, TRPA1, TRP Channel, TRPChannel, TRPV Channel, TRPM8, TRPV3, TRPVChannel, Transient receptor potential channels

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Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

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Protocol Information

beta-Eudesmol (orb1303641)

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Available Sizes

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1 mg
$ 90.00
1 ml x 10 mM (in DMSO)
$ 160.00
5 mg
$ 160.00
10 mg
$ 220.00
25 mg
$ 340.00
DispatchUsually dispatched within 3-5 working days
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