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Bicuculline

SKU: orb1304933

Description

Bicuculline is a natural alkaloid that acts as a competitive GABAA receptor antagonist (IC50 = 2 µM) and a blocker of SK potassium channels. It is widely utilized in neuroscience research to induce seizures in animal models and to study synaptic inhibition and neuronal excitability in vitro.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Images & Validation

Key Properties

CAS Number485-49-4
MW367.35
Purity99.99% (May vary between batches)
FormulaC20H17NO6
SMILES[H][C@]1(OC(=O)c2c3OCOc3ccc12)[C@@]1([H])N(C)CCc2cc3OCOc3cc12
TargetGABA Receptor
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.44 mM);DMSO:16.67 mg/mL (45.38 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

Target IC50
GABAA receptor:2 μM
In Vivo
(+)-Bicuculline, at concentrations of 1/3 μM, increased the EC50 of gamma-aminobutyric acid (GABA) by 1.6 times (41.0-67.0 μM) and by 3.6 times (36.1-129.0 μM), respectively. This compound also dose-dependently inhibited the Cl- conductance induced by GABA (40 μM) in the range of 1-100 μM. In addition, (+)-Bicuculline inhibited the agonistic effects of GABA (40 μM) on the α1β2γ2L receptor, functioning as an antagonist of the α1β2γ2L GABAA receptor. This action caused a parallel shift in the concentration-effect curve of GABA without affecting its maximum response. Furthermore, (+)-Bicuculline also exhibited inhibitory effects on Ca2+-activated potassium channels.

Storage & Handling

Storage-20°C
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Bicuculline, (+)-Bicuculline, AHP, alkaloid, d-Bicuculline, convulsant, competitive, inhibit, neurotransmitter, Inhibitor, GABAR, GABA Receptor, GABAReceptor, Gamma-aminobutyric acid Receptor, potassium, γ-Aminobutyric acid Receptor

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Quality Guarantee

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Key Properties

No computed properties available.

Protocol Information

Available Sizes

Select a size below

10 mg
$ 70.00
1 ml x 10 mM (in DMSO)
$ 90.00
25 mg
$ 90.00
50 mg
$ 110.00
100 mg
$ 130.00
DispatchUsually dispatched within 5-10 working days
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