Cart summary

You have no items in your shopping cart.

BMS 195614

SKU: orb1704871

Description

BMS 195614 is a selective retinoic acid receptor alpha (RARα) antagonist that binds specifically to the RARα subunit. This small molecule is a valuable research tool for investigating RARα function in cellular differentiation and proliferation assays, both in vitro and in vivo.

Research Area

Metabolism Research

Images & Validation

Key Properties

CAS Number253310-42-8
MW448.51
Purity97.70% (May vary between batches)
FormulaC29H24N2O3
SMILESCC1(CC=C(C2=C1C=CC(=C2)C(=O)NC3=CC=C(C=C3)C(=O)O)C4=CC5=CC=CC=C5N=C4)C
TargetRetinoid Receptor
SolubilityDMSO:10.1 mg/mL (22.52 mM)

Bioactivity

In Vivo
BMS 195614 displayed poor in vivo activity in mice when administered orally. Treatment with BMS 195614 at oral doses for 1 month showed no inhibition to spermatogenesis . Oral administration of BMS 195614 did not suppress spermatogenesis in mice .
In Vitro
BMS 195614 reversed the induction effect of selective RARα agonists, AM580, AM80 and BMS 194753 on differentiation of the acute promyelocytic leukemia cell lines, NB4 and HL60 . Treatment with retinoic acid (RA) (1 uM) for 72 hrs significantly reduced T47D breast cancer cells migration. But RA in combination with BMS 195614 did not affect the cell movement . In cells of a bovine stromal-vascular fraction from intramuscular fat, BMS 195614 significantly diminished the anti-adipogenic effect of ATRA .

Storage & Handling

StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

182135-66-6, BMS 195614, BMS 614, BMS195614, BMS-195614, BMS614, BMS-614, RetinoidReceptor, Retinoid Receptor, RARα

Similar Products

  • BMS-195614 [orb1785921]

    >98%

    182135-66-6

    448.512467384338

    C29H24N2O3

    100 mg, 1 g, 250 mg
Quality Guarantee

Quality Guarantee

Explore bioreagents carefree to elevate your research. All our products are rigorously tested for performance. If a product does not perform as described on its datasheet, our scientific support team will provide expert troubleshooting, a prompt replacement, or a refund. For full details, please see our Terms & Conditions and Buying Guide. Contact us at support@biorbyt.com.

Key Properties

No computed properties available.

Documents Download

Datasheet
Product Information
Download

Request a Document

Protocol Information

BMS 195614 (orb1704871)

  • Star
  • Star
  • Star
  • Star
  • Star
  • 0.0
Based on 0 reviews

Participating in our Biorbyt product reviews program enables you to support fellow scientists by sharing your firsthand experience with our products.

Login to Submit a Review

No reviews yet

Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

Step 2: Enter the in vivo formulation

(This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 230.00
5 mg
$ 460.00
10 mg
$ 660.00
25 mg
$ 1,030.00
50 mg
$ 1,370.00
100 mg
$ 1,820.00
500 mg
$ 3,620.00
DispatchUsually dispatched within 3-5 working days
Bulk Enquiry