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Boldine

SKU: orb1220722

Description

Boldine is a natual product .Boldine displays anti-cancer cytoprotective anti-oxidant and anti-inflammatory activities.

Images & Validation

Key Properties

CAS Number476-70-0
MW327.37
Purity>98% (HPLC)
FormulaC19H21NO4
SMILES[H][C@@]12Cc3cc(O)c(OC)cc3-c3c(OC)c(O)cc(CCN1C)c23
TargetOPG |RANKL| RANK
SolubilityDMSO:65 mg/mL (198.55 mM)

Bioactivity

In Vivo
Animal model: DSS-induced mice model. Dosage: 50 mg/kg. Administration: p.o. Result: Reduced the expression of CD 68+ and activity of myeloperoxidase (MPO). Attenuated Pro-Inflammatory Cytokines and the level of malondialdehyde (MDA). Increased the Activities of Enzymic Antioxidants and Inhibited p65-NF-κB and STAT3 Activity.
In Vitro
Cell Viability Assay Cell line: T24 and RT4. Concentration: 10, 50, 100, 200, 300, 400, 500 μM. Incubation time: 24 h. Result: Inhibited cell growth. Apoptosis Analysis Cell line: T24. Concentration: 200, 400 μM. Incubation time: 24 h. Result: Caused a G2/M-phase arrest and a marked increase in cell death Western blot analysis. Cell line: T24. Concentration: 200, 400 μM. Incubation time: 1,, 3, 24 h. Result: Decreased the level of p-ERK after 24 hours with 200 μM and after 3 and 24 hours with 400 μM. The anti-p-cdc2 antibody did not demonstrate any difference in the phosphorylation status of cdc2.Decreased the phosphorylation of GSK-3β after 24 hours at a concentration of 400 μM.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

110-Dimethoxy-29-dihydroxyaporphine | ex Peumus boldus

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Quality Guarantee

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Protocol Information

Boldine (orb1220722)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

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200 mg
500 mg
10 mg
$ 90.00
25 mg
$ 130.00
50 mg
$ 190.00
100 mg
$ 280.00