Boldine

SKU: orb1301554

Description

Boldine (1,10-Dimethoxy-2,9-dihydroxyaporphine) is a natural aporphine alkaloid with demonstrated antioxidant, anti-inflammatory, and cytoprotective properties. Its anti-cancer potential has been investigated in vitro and in vivo, making it a compound of interest for research in oncology and inflammation-related diseases.

Research Area

Cell Biology, Signal Transduction

Images & Validation

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Key Properties

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CAS Number	476-70-0
MW	327.37
Purity	98.53%
Formula	C₁₉H₂₁NO₄
SMILES	[H][C@@]12Cc3cc(O)c(OC)cc3-c3c(OC)c(O)cc(CCN1C)c23
Target	RANKL/RANK,Apoptosis
Solubility	10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.11 mM);DMSO:65 mg/mL (198.55 mM)

Bioactivity

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In Vivo	Boldine reduced oxidative stress and improved endothelium-dependent relaxation in aortas of diabetic mice largely through inhibiting ROS overproduction associated with Ang II-mediated BMP4-dependent mechanisms. Read more...
In Vitro	Boldine was able to reduce cell viability and cell proliferation in T24 cells. In addition, boldine arrests the cell cycle at G2/M-phase and cause cell death by apoptosis. Boldine-induced inhibition of cell growth and cell cycle arrest appears to be linked to inactivation of extracellular signal-regulated kinase protein (ERK). Additionally, the efficacy of boldine in apoptosis-induced in T24 cells is correlated with modulation of AKT (inactivation) and glycogen synthase kinase-3β (GSK-3β) (activation) proteins. Read more...
Cell Research	Sulforhodamine B assay, Tetrazolium reduction assay, Flow Cytometry Analysis, Ecto-5'-nucleotidase activity and Western blot assay were performed.
Animal Research	Vascular reactivity was studied in mouse aortas from db/db diabetic and normal mice. Reactive oxygen species (ROS) production, angiotensin AT1 receptor localization and protein expression of oxidative stress markers in the vascular wall were evaluated by dihydroethidium fluorescence, lucigenin enhanced-chemiluminescence, immunohistochemistry and Western blot respectively. Primary cultures of mouse aortic endothelial cells, exposed to high concentrations of glucose (30 mmol L(-1) ) were also used. Read more...

Storage & Handling

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Storage	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice/Shipping at ambient temperature.
Expiration Date	12 months from date of receipt.
Disclaimer	For research use only

Alternative Names

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OPG, inhibit, ex Peumus boldus, Inhibitor, 1,10-Dimethoxy-2,9-dihydroxyaporphine, Boldine, RANKL, RANK

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Compound Identifiers

PubChem CID

10154 ↗

Key Properties

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No computed properties available.

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Boldine (orb1301554)

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CAS Number:	72584-75-9
MW:	411.45
Formula:	C₂₃H₂₅NO₆

Purity:	>98% (HPLC)
CAS Number:	476-70-0
MW:	327.37
Formula:	C₁₉H₂₁NO₄

Boldine

Description

Research Area

Images & Validation

Key Properties

Bioactivity

Storage & Handling

Alternative Names

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