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Bruceine A

SKU: orb1304648

Description

Bruceine A (NSC-31616), a natural quassinoid isolated from Brucea javanica, is a research compound with demonstrated anti-parasitic activity. Studies indicate its potential for canine babesiosis treatment, supported by in vitro assays and in vivo experimental models investigating its mechanism of action.

Research Area

Cell Biology, Infectious Disease & Virology, Metabolism Research, Signal Transduction

Images & Validation

Key Properties

CAS Number25514-31-2
MW522.54
Purity99.85%
FormulaC26H34O11
SMILES[H][C@]12[C@@H](OC(=O)CC(C)C)C(=O)O[C@]3([H])C[C@@]4([H])C(C)=C(O)C(=O)C[C@]4(C)[C@@]4([H])[C@@H](O)[C@H](O)[C@]1(OC[C@@]234)C(=O)OC
TargetPhosphatase,Parasite,p38 MAPK,NF-κB,Apoptosis,Antibiotic
Solubility10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3.83 mM);DMSO:26.39 mg/mL (50.5 mM)

Bioactivity

In Vivo
Oral administration of bruceine A at a dosage of 6.4 mg/kg/day for 5 days resulted in no clinical findings in a dog with normal ranges of hematological and biochemical values in the blood. Three dogs were infected with B. gibsoni and two of them were treated with bruceine A at a dosage of 6.4 mg/kg/day for 6 days from day 5 post-infection.
In Vitro
Bruceine A inhibited the in vitro growth of Babesia gibsoni in canine erythrocytes at lower concentration compared with the standard antibabesial drug diminazene aceturate and killed the parasites within 24 hr at a concentration of 25 nM.

Storage & Handling

Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Inhibitor, NSC 310616, NSC 31616, inhibit, NSC310616, NSC-310616, NSC31616, NSC-31616, Parasite, Bruceine A, Antibiotic, Dihydrobrusatol

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Quality Guarantee

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Key Properties

No computed properties available.

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Bruceine A (orb1304648)

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% DMSO +
%+
% Tween 80 +
%

Available Sizes

Select a size below

1 mg
$ 100.00
5 mg
$ 170.00
1 ml x 10 mM (in DMSO)
$ 180.00
10 mg
$ 220.00
25 mg
$ 340.00
50 mg
$ 500.00
100 mg
$ 720.00
DispatchUsually dispatched within 3-5 working days
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