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bruceine B

SKU: orb3027291

Description

Bruceine B, a potent inhibitor of leukocyte-endothelial cell adhesion, may have anti-inflammatory activity, it can inhibit neutrophil adhesion to lipopolysaccharide-stimulated HUVEC and T cell adhesion to TNF-stimulated HUVEC.

Research Area

Cell Biology, Infectious Disease & Virology

Images & Validation

Key Properties

CAS Number25514-29-8
MW480.5
Purity99.85%
FormulaC23H28O11
SMILES[H][C@]12[C@@H](OC(C)=O)C(=O)O[C@]3([H])C[C@@]4([H])C(C)=C(O)C(=O)C[C@]4(C)[C@@]4([H])[C@@H](O)[C@H](O)[C@]1(OC[C@@]234)C(=O)OC
TargetTNF,Parasite

Bioactivity

In Vivo
Leukocyte adhesion to vascular endothelial cells is an essential step in the development of inflammatory diseases. inhibitors of leukocyte-endothelial cell adhesion that could be used as anti-inflammatory drugs and found that bruceine B (0.2 microgram/ml; 0.44 microM) inhibited human neutrophil or T cell adhesion to tumor necrosis factor-alpha (TNF) stimulated human umbilical vein endothelial cells (HUVEC).

Storage & Handling

Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

Brucein B, bruceine B, Inhibitor, Parasite, inhibit, TNF-α

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  • bruceine B [orb1220748]

    >98% (HPLC)

    25514-29-8

    480.5

    C23H28O11

    500 mg, 200 mg, 100 mg, 1 g, 5 mg
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bruceine B (orb3027291)

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Available Sizes

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1 mg
$ 170.00
5 mg
$ 370.00
10 mg
$ 580.00
25 mg
$ 900.00
50 mg
$ 1,160.00
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