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CA-4948

SKU: orb1225891

Description

CA-4948 (AU-4948) is a novel potent, selective, orally bioavailable IRAK4 inhibitor; shows in vivo activity in TLR4-induced cytokine release model, exhibits dose-dependent efficacy in ABC-DLBCL MYD88-L265P xenograft tumor models; a therapeutic agent for hematological cancers with dysregulated TLR/MYD88/IRAK4 signaling, induces tumor regression in an ABC-DLBCL xenograft model combined with Venetoclax.Blood Cancer Phase 1 Clinical(In Vitro):IRAK4-IN-7 has anti-cancer and anti-inflammatory activities, it can be used for cancer and inflammatory diseases treatment.

Images & Validation

Key Properties

CAS Number1801343-74-7
MW417.429
Purity>98% (HPLC)
FormulaC21H19N7O3
SMILESO=C(C1=CC=CC(C2=CC=C(N)N=C2)=N1)NC3=CN=C4C(OC(N5CCOCC5)=N4)=C3
TargetIRAK
SolubilityDMSO : 13.89 mg/mL 33.28 mM;H2O : < 0.1 mg/mL

Bioactivity

In Vivo
IRAK4-IN-7 has anti-cancer and anti-inflammatory activities, it can be used for cancer and inflammatory diseases treatment.

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

CA 4948 | CA4948 | AU-4948 | AU 4948 | AU4948

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Protocol Information

CA-4948 (orb1225891)

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Step 1: Enter information below

(Recommended: An additional animal making an allowance for loss during the experiment)

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% DMSO +
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Available Sizes

Select a size below

200 mg
500 mg
2 mg
$ 90.00
5 mg
$ 130.00
10 mg
$ 190.00
25 mg
$ 320.00
50 mg
$ 510.00
100 mg
$ 740.00